- 荨麻根提取物 (Nettle Root):在欧洲,荨麻根提取物广泛用于BPH的治疗。有一项涉及558例患者的双盲对照研究,分别给予患者安慰剂或者荨麻根提取物,为期半年。结果显示荨麻根提取物的疗效明显要比安慰剂好。在另外3项双盲研究中也得出同样的结果。
- β-谷甾醇 (Beta-sitosterol):它是植物提取物。有几项临床研究支持β-谷甾醇治疗BPH的有效性。其中最大规模的一项研究,有200位BPH患者参与,为期6个月。研究结束后,再随访多数参与者一年。结果在这一年中β-谷甾醇的疗效一直在持续。
- 草花粉提取物 (Grass pollen):用于治疗BPH的草花粉制剂是由92%的黑麦、5%的梯牧草及3%的玉米组成,同时除去了它们的过敏性成分。有两项双盲研究均发现草花粉提取物能改善前列腺增生的症状。其中一项研究还发现服用草花粉提取物的患者他们的前列腺明显缩小。但尚未明确草花粉的作用原理。其中一个学说认为草花粉能抑制体内前列腺素和白三烯等介质的产生,从而通过减少前列腺炎症来缓解前列腺充血。
- 联合治疗:一项为期48周,共涉及543例早期BPH患者的双盲研究比较了联合使用锯叶棕和荨麻根提取物与使用保列治药物治疗之间的差异。结果发现两者疗效相当。另一项双盲研究发现相同的联合使用效果优于安慰剂。而一项为期3个月共有144例患者参与的双盲研究发现使用一种含有锯叶棕、草花粉提取物、β-谷甾醇和维生素E的产品能显著缓解BPH症状。
- 其它可能有效的天然疗法:有一项研究显示口服绿茶提取物能缓解BPH症状,但证据不强。南瓜子可能也有一定的效果。一项初步双盲试验发现口服亚麻子提取物 (Flaxseed) 四个月能适度改善BPH症状。
良性前列腺增生自然疗法
参考文献
- Emili E, Lo Cigno M, Petrone U. Clinical trial of a new drug for treating hypertrophy of the prostate (Permixon®) [in Italian]. Urologia. 1983;50:1042-1048.
- Champault G, Patel JC, Bonnard AM. A double-blind trial of an extract of the plant Serenoa repens in benign prostatic hyperplasia. Br J Clin Pharmacol. 1984;18:461-462.
- Tasca A, Barulli M, Cavazzana A, et al. Treatment of obstructive symptomology caused by prostatic adenoma using an extract of Serenoa repens. Double-blind clinical study vs. placebo [in Italian; English abstract]. Minerva Urol Nefrol. 1985;37:87-91.
- Boccafoschi C, Annoscia S. Comparison of Serenoa repens extract with placebo by controlled clinical trial in patients with prostatic adenomatosis [in Italian]. Urologia. 1983;50:1257-1268.
- Smith HR, Memon A, Smart CJ, et al. The value of Permixon® in benign prostatic hypertrophy. Br J Urol. 1986;58:36-40.
- Descotes JL, Rambeaud JJ, Deschaseaux P, et al. Placebo-controlled evaluation of the efficacy and tolerability of Permixon® in benign prostatic hyperplasia after exclusion of placebo responders. Clin Drug Invest. 1995;9:291-297.
- Mattei FM, Capone M, Acconcia A. Serenoa repens extract in the medical treatment of benign prostatic hypertrophy [in Italian]. Urologia. 1988;55:547-552.
- Bombardelli E, Morazzoni P. Prunus africana (Hook f.) kalkm. Fitoterapia. 1997;68:205-218.
- Bongi G. Tadenan in the treatment of prostatic adenoma. Anatomo-clinical study [in Italian]. Minerva Urol. 1972;24:129-139.
- Rizzo M. Terapia medica dell'adenoma della prostata: Valutazione clinica comparativa tra estratto di Pygeum africanum ad alte dosi e placebo. Farmacia Terapia. 1985;2:105-110.
- Ranno S, Minaldi G, Viscusi G, et al. Efficacy and tolerability of prostate adenoma treatment with Tadenan 50 [in Italian; English abstract]. Prog Med. 1986;42:165-169.
- Bassi P, Artibani W, De Luca V, et al. Standardized extract of Pygeum africanum in the treatment of benign prostatic hypertrophy. Controlled clinical study versus placebo [in Italian]. Minerva Urol Nefrol. 1987;39:45-50.
- Andro MC, Riffaud JP. Pygeum africanum extract for the treatment of patients with benign prostatic hyperplasia: a review of 25 years of published experience. Curr Ther Res. 1995;56:796-817.
- Kozai K, Miyake Y, Kohda H, et al. Inhibition of glucosyltransferase from Streptococcus mutans by oleanolic acid and ursolic acid. Caries Res. 1987;21:104-108.
- Yablonsky F, Nicolas V, Riffaud JP, et al. Antiproliferative effect of Pygeum africanum extract on rat prostatic fibroblasts. J Urol. 1997;157:2381-2387.
- Vontobel HP, Herzog R, Rutishauser G, et al. Results of a double-blind study on the effectiveness of ERU (extractum radicis Urticae) capsules in conservative treatment of benign prostatic hyperplasia [translated from German]. Urologe A. 1985;24:49-51.
- Dathe G, Schmid H. Phytotherapy of benign prostate hyperplasia (BPH); double-blind study with stinging nettle root extract (Extractum Radicis Urticae—ERU) [translated from German]. Urologe B. 1987;27:223-226.
- European Scientific Cooperative on Phytotherapy. Urticae radix. Exeter, UK: ESCOP; 1996-1997; Monographs on the Medicinal Uses of Plant Drugs, Fascicule 2:4.
- Berges RR, Kassen A, Senge T. Treatment of symptomatic benign prostatic hyperplasia with beta-sitosterol: an 18-month follow-up. BJU Int. 2000;85:842-846.
- Becker H, Ebeling L. Conservative therapy of benign prostate hyperplasia (BPH) with Cernilton®N. Results of a placebo-controlled double-blind study [translated from German]. Urologe [B]. 1988;28:301-306.
- Buck AC, Cox R, Rees RWM, et al. Treatment of outflow tract obstruction due to benign prostatic hyperplasia with the pollen extract, Cernilton: a double-blind, placebo-controlled study. Br J Urol. 1990;66:398-404.
- Loschen G, Ebeling L. Inhibition of the arachidonate metabolism by an extract of rye pollen [in German; English abstract]. Arzneimittelforschung. 1991;41:162-167.
- Sokeland J. Combined sabal and urtica extract compared with finasteride in men with benign prostatic hyperplasia: analysis of prostate volume and therapeutic outcome. BJU Int. 2000;86:439-442.
- Wilt T, Ishani A, MacDonald R, et al. Pygeum africanum for benign prostatic hyperplasia. Cochrane Database Syst Rev. 2002;1:CD001044.
- Gerber GS, Kuznetsov D, Johnson BC, et al. Randomized, double-blind, placebo-controlled trial of saw palmetto in men with lower urinary tract symptoms. Urology. 2001;58:960-964.
- Preuss HG, Marcusen C, Regan J, et al. Randomized trial of a combination of natural products (cernitin, Saw Palmetto, B-sitosterol, vitamin E) on symptoms of benign prostatic hyperplasia (BPH). Int Urol Nephrol. 2001;33:217-225.
- Willetts KE, Clements MS, Champion S, et al. Serenoa repens extract for benign prostate hyperplasia: a randomized controlled trial. BJU Int. 2003;92:267-270.
- Bent S, Kane C, Shinohara K, et al. Saw Palmetto for Benign Prostatic Hyperplasia. N Engl J Med. 2006;354:557-66.
- Bettuzzi S, Brausi M, Rizzi F, et al. Chemoprevention of Human Prostate Cancer by Oral Administration of Green Tea Catechins in Volunteers with High-Grade Prostate Intraepithelial Neoplasia: A Preliminary Report from a One-Year Proof-of-Principle Study. Cancer Res. 2006;66:1234-1240.
- Zhang W, Wang X, Liu Y, et al. Effects of dietary flaxseed lignan extract on symptoms of benign prostatic hyperplasia. J Med Food. 2008 Mar 21.
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